2025

Astrocytes as Metabolic Sensors Orchestrating Energy‐Driven Brain Vulnerability in Alzheimer’s Disease

Leyre Sánchez de Muniain, Paula Escalada, María J. Ramírez, Maite Solas

Journal of Neurochemistry · 6 October 2025

Alzheimer's disease (AD), the leading neurodegenerative disorder linked to aging, emerges within a paradoxical metabolic landscape. Despite rising cellular energy demands due to accumulated damage and stress, overall energy expenditure…

Embracing the modern biochemistry of brain metabolism

Juan P Bolaños, Cristina M Alberini, Angeles Almeida, L Felipe Barros, Gilles Bonvento, Anne‐Karine Bouzier‐Sore, Ralf Dringen, Giles E Hardingham, Johannes Hirrlinger, Pierre J Magistretti, Giovanni Marsicano, Klaus‐Armin Nave, Rosa C Paolicelli, Luc Pellerin, Pierre‐Yves Plaçais, Thomas Preat, Nathalie Rouach, Ivan Ruminot, Aiman S Saab, Carmen Sandi, Stefanie Schirmeier, Avital Schurr, Jimena Sierralta, Maite Solas, Vanja Tepavcevic, Bruno Weber, Eduardo R Zimmer

Journal of neurochemistry · 21 July 2025

This editorial challenges the long‐held neuron‐centered view of brain metabolism, relying on ample evidence that it is a cooperative, multicellular process. Astrocytes, oligodendrocytes, and other glia play active roles providing…

2024

Novel Pitolisant-Derived Sulfonyl Compounds for Alzheimer Disease

Silvia Pérez-Silanes, Eva Martisova, Esther Moreno, Maite Solas, Daniel Plano, Carmen Sanmartin, María Javier Ramírez

MDPI · 8 January 2024

Alzheimer’s disease (AD) is a complex and multifactorial neurodegenerative disorder characterized by cognitive decline, memory loss, behavioral changes, and other neurological symptoms. Considering the urgent need for new AD therapeutics,…

2018

Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target

Manuel H Janeiro, María J Ramírez, Fermin I Milagro, J Alfredo Martínez, Maite Solas

MDPI · 1 October 2018

Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several factors including diet, gut microbial…